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In addition to The Duke de Maine seeing that the mishap which he wished to others fel vpon him, tooke his way with great terrour toward Iury, leauing behind his ordinance, bagge and baggage, and as many beside as could not runne away so swiftly as he did, the great kill· Deuils Don Pedro Moreo, and Don Iuan de Cordoua, two Spanish Moores, with such as could follow them ran after him.—Antony Colynet, than a deck of playing cards.However, once upon a time a simple deck of cards was viewed as a gateway to far more pernicious activities than simple games such as Old Maid or Whist.
moonshot (n.): A term that originated with the Apollo program and has since been co-opted by Google, the MD Anderson Cancer Center, and, most recently, the vice president of the United States.For example, while some might see losing one’s job as bad, others might call it a clearing event for employment opportunities to come.“Forty-four-month median OS in patients treated with Afinitor compared to 37.7 months for the placebo/crossover arm; not statistically significant but clinically meaningful.” — an ad for a Novartis cancer drug, spotted by gene therapy (n.): A once-definite phrase that has since nebulously expanded to cover, it seems, all of biotech.Ambrose Bierce began “The Devil’s Dictionary” in the late 1800s, creating a satirical lexicon he updated weekly before wandering off to Mexico to die.We sought to replicate at least part of that story — hence, The Biotech Devil’s Dictionary.“Ultra-deep sequencing to detect circulating tumor DNA has the potential to be the Holy Grail for early cancer detection in asymptomatic individuals.” — the press materials from a diagnostics company that one-upped everyone by actually naming itself “Grail“ human capital (n.): An ironically dehumanizing phrase used to liken living, breathing people to business assets, which is either a terrifying glimpse of the future or a clever bit of Marxist commentary.
“Bolstered human capital, technology platform and financial position as we expand our fully integrated organization” — Spark Therapeutics, explaining in an earnings report that it hired a new chief scientific officer.
But this guide was created to help you navigate your way through all those adjectives and shed the only light you’ll ever need on an otherwise confusing, strenuous experience.
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transformational (adj.) and unmet need (n.): A pair of phrases one can weave into really any sentence about a new drug, as literally no one in the history of biopharma has touted its milquetoast pipeline of treatments for diseases that are perfectly well served already.
undruggable (adj.): A word meant to describe biological targets that cannot be reached by medicine, it is used almost exclusively by people at companies working on medicines for exactly those targets, thereby negating their “undruggability” and turning the phrase into nonsense on the order of “idiot-proof.” “In truth, I hate the term ‘undruggable,’ because it hamstrings the creative mindset necessary to hit a previously unaccessible target.” — Dr.
At the last moment, as in The police arrived in the nick of time, or He got there just in time for dinner.